Research has also confirmed that substances similar to melatonin also have an important protective role against oxidative damage and inflammatory and recovery of complex I activity, the inhibition is a fundamental pathophysiological event in the development of Parkinson's disease, reported the University of Granada.
The finding could have an important consequence for the design of new drugs that help prevent the disease, according to investigators.
Parkinson's disease is a 40% reduction in the activity of complex I of the electron transport chain in the substantia nigra of these patients, with a loss of between 70 and 80% of the neurons located in this tissue before symptoms appear.
In mice treated for this study, the activity of complex I is reduced by 65% \u200b\u200bin the substantia nigra, and treatment with melatonin or its structural analogues counteract this reduction, normalizing mitochondrial function.
Part of the results of work have been published in scientific journals Journal of Neuroscience Research and European Journal of Medicinal Chemistry.
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